Summary:
Recombinant human RGR protein
Cat：P03892
| 【Derived From】： E.coli |
| 【Endotoxin】： Not measured |
| 【Amino Acid】： 1-291aa |
| 【Purity】： ≥85% by SDS-PAGE. |
| 【Name】： RGR |
| 【Full Name】： retinal G protein coupled receptor |
| 【Uniprot】： P47804 |
| 【Gene ID】： 5995 |
| 【Species Reactivity】： Human Mouse (Bovine) |
| 【Mol Mass】： 32kDa |
| 【Application】： Immunology research |
| 【Purification】： NI-NTA affinity purification |
| 【Bioactive】： N0 |
| 【Tag】： With a 6×His tag at the N/C-terminus. |
| 【Concentration】： 1mg/ml by SDS-PAGE. |
Store:
| 【Reconstitution】： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| 【Storage】： Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year. |
| 【Formulation】： Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
Background:
This gene encodes a putative retinal G-protein coupled receptor.The gene is a member of the opsin subfamily of the 7 transmembrane, G-protein coupled receptor 1 family.Like other opsins which bind retinaldehyde, it contains a conserved lysine residue in the seventh transmembrane domain.The protein acts as a photoisomerase to catalyze the conversion of all-trans-retinal to 11-cis-retinal.The reverse isomerization occurs with rhodopsin in retinal photoreceptor cells.The protein is exclusively expressed in tissue adjacent to retinal photoreceptor cells, the retinal pigment epithelium and Mueller cells.This gene may be associated with autosomal recessive and autosomal dominant retinitis pigmentosa (arRP and adRP, respectively).Alternative splicing results in multiple transcript variants encoding different isoforms
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