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Recombinant human TYROBP protein

Cat：P03937

Summary:

【Derived From】： E.coli

【Endotoxin】： Not measured

【Amino Acid】： 1-113aa

【Purity】： ≥85% by SDS-PAGE.

【Name】： TYROBP

【Full Name】： TYRO protein tyrosine kinase binding protein

【Uniprot】： O43914

【Gene ID】： 7305

【Species Reactivity】： Human Mouse Rat (Gorilla Bovine Pig)

【Mol Mass】： 12kDa

【Application】： Immunology research

【Purification】： NI-NTA affinity purification

【Bioactive】： N0

【Tag】： With a 6×His tag at the N/C-terminus.

【Concentration】： 1mg/ml by SDS-PAGE.

Store:

【Reconstitution】： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.)

【Storage】： Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year.

【Formulation】： Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0.

Background:

This gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain.The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element.This protein may bind zeta-chain (TCR) associated protein kinase 70kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation.Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease.Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL.Multiple alternative transcript variants encoding distinct isoforms have been identified for this gene.

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