Summary:
Recombinant human HDAC3 protein
Cat：P03954
| 【Derived From】： E.coli |
| 【Endotoxin】： Not measured |
| 【Amino Acid】： 79-428aa |
| 【Purity】： ≥85% by SDS-PAGE. |
| 【Name】： HDAC3 |
| 【Full Name】： histone deacetylase 3 |
| 【Uniprot】： O15379 |
| 【Gene ID】： 8841 |
| 【Species Reactivity】： Human Mouse Rat (Chicken Gorilla) |
| 【Mol Mass】： 39kDa |
| 【Application】： Immunology research |
| 【Purification】： NI-NTA affinity purification |
| 【Bioactive】： N0 |
| 【Tag】： With a 6×His tag at the N/C-terminus. |
| 【Concentration】： 1mg/ml by SDS-PAGE. |
Store:
| 【Reconstitution】： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| 【Storage】： Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year. |
| 【Formulation】： Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
Background:
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events.Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA.The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family.It has histone deacetylase activity and represses transcription when tethered to a promoter.It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1.This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis.This gene is regarded as a potential tumor suppressor gene.
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