Summary:
Recombinant human BPGM protein
Cat：P04028
| 【Derived From】： E.coli |
| 【Endotoxin】： Not measured |
| 【Amino Acid】： 1-260aa |
| 【Purity】： ≥85% by SDS-PAGE. |
| 【Name】： BPGM |
| 【Full Name】： 2，3-bisphosphoglycerate mutase |
| 【Uniprot】： P07738 |
| 【Gene ID】： 669 |
| 【Species Reactivity】： Human Mouse (Bovine Rabbit) |
| 【Mol Mass】： 30kDa |
| 【Application】： Immunology research |
| 【Purification】： NI-NTA affinity purification |
| 【Bioactive】： N0 |
| 【Tag】： With a 6×His tag at the N/C-terminus. |
| 【Concentration】： 1mg/ml by SDS-PAGE. |
Store:
| 【Reconstitution】： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| 【Storage】： Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year. |
| 【Formulation】： Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
Background:
2,3-diphosphoglycerate (2,3-DPG) is a small molecule found at high concentrations in red blood cells where it binds to and decreases the oxygen affinity of hemoglobin.This gene encodes a multifunctional enzyme that catalyzes 2,3-DPG synthesis via its synthetase activity, and 2,3-DPG degradation via its phosphatase activity.The enzyme also has phosphoglycerate phosphomutase activity.Deficiency of this enzyme increases the affinity of cells for oxygen.Mutations in this gene result in hemolytic anemia.Multiple alternatively spliced variants, encoding the same protein, have been identified.
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