Summary:
Recombinant human MARK3 protein
Cat：P04080
| 【Derived From】： E.coli |
| 【Endotoxin】： Not measured |
| 【Amino Acid】： 42-392aa |
| 【Purity】： ≥85% by SDS-PAGE. |
| 【Name】： MARK3 |
| 【Full Name】： MAP/microtubule affinity-regulating kinase 3 |
| 【Uniprot】： P27448 |
| 【Gene ID】： 4140 |
| 【Species Reactivity】： Human Mouse Rat |
| 【Mol Mass】： 39kDa |
| 【Application】： Immunology research |
| 【Purification】： NI-NTA affinity purification |
| 【Bioactive】： N0 |
| 【Tag】： With a 6×His tag at the N/C-terminus. |
| 【Concentration】： 1mg/ml by SDS-PAGE. |
Store:
| 【Reconstitution】： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| 【Storage】： Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year. |
| 【Formulation】： Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
Background:
Serine/threonine-protein kinase (PubMed:23666762).Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4.Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762).Phosphorylates CDC25C on 'Ser-216'.Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus (PubMed:16980613).Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1.Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1 (PubMed:28087714).
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