Summary:
Recombinant human GCDH protein
Cat：P04081
| 【Derived From】： E.coli |
| 【Endotoxin】： Not measured |
| 【Amino Acid】： 89-437aa |
| 【Purity】： ≥85% by SDS-PAGE. |
| 【Name】： GCDH |
| 【Full Name】： glutaryl-Coenzyme A dehydrogenase |
| 【Uniprot】： Q92947 |
| 【Gene ID】： 2639 |
| 【Species Reactivity】： Human Mouse (Pig Bovine A.thaliana) |
| 【Mol Mass】： 38kDa |
| 【Application】： Immunology research |
| 【Purification】： NI-NTA affinity purification |
| 【Bioactive】： N0 |
| 【Tag】： With a 6×His tag at the N/C-terminus. |
| 【Concentration】： 1mg/ml by SDS-PAGE. |
Store:
| 【Reconstitution】： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| 【Storage】： Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year. |
| 【Formulation】： Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
Background:
The protein encoded by this gene belongs to the acyl-CoA dehydrogenase family.It catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism.It uses electron transfer flavoprotein as its electron acceptor.The enzyme exists in the mitochondrial matrix as a homotetramer of 45-kD subunits.Mutations in this gene result in the metabolic disorder glutaric aciduria type 1, which is also known as glutaric acidemia type I.Alternative splicing of this gene results in multiple transcript variants.A related pseudogene has been identified on chromosome 12.
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