Summary:
Recombinant human DUSP7 protein
Cat：P04136
| 【Derived From】： E.coli |
| 【Endotoxin】： Not measured |
| 【Amino Acid】： 1-321aa |
| 【Purity】： ≥85% by SDS-PAGE. |
| 【Name】： DUSP7 |
| 【Full Name】： dual specificity phosphatase 7 |
| 【Uniprot】： Q16829 |
| 【Gene ID】： 1849 |
| 【Species Reactivity】： Human Mouse Rat |
| 【Mol Mass】： 35kDa |
| 【Application】： Immunology research |
| 【Purification】： NI-NTA affinity purification |
| 【Bioactive】： N0 |
| 【Tag】： With a 6×His tag at the N/C-terminus. |
| 【Concentration】： 1mg/ml by SDS-PAGE. |
Store:
| 【Reconstitution】： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| 【Storage】： Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year. |
| 【Formulation】： Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
Background:
Dual specificity protein phosphatase.Shows high activity towards MAPK1/ERK2.Also has lower activity towards MAPK14 and MAPK8.In arrested oocytes, plays a role in meiotic resumption (By similarity).Promotes nuclear envelope breakdown and activation of the CDK1/Cyclin-B complex in oocytes, probably by dephosphorylating and inactivating the conventional protein kinase C (cPKC) isozyme PRKCB (By similarity).May also inactivate PRKCA and/or PRKCG (By similarity).Also important in oocytes for normal chromosome alignment on the metaphase plate and progression to anaphase, where it might regulate activity of the spindle-assembly checkpoint (SAC) complex (By similarity).
Verified picture
