Summary:
Recombinant human DDX3X protein
Cat：P04142
| 【Derived From】： E.coli |
| 【Endotoxin】： Not measured |
| 【Amino Acid】： 313-662aa |
| 【Purity】： ≥85% by SDS-PAGE. |
| 【Name】： DDX3X |
| 【Full Name】： DEAD (Asp-Glu-Ala-Asp) box polypeptide 3，X-linked |
| 【Uniprot】： O00571 |
| 【Gene ID】： 1654 |
| 【Species Reactivity】： Human Mouse |
| 【Mol Mass】： 39kDa |
| 【Application】： Immunology research |
| 【Purification】： NI-NTA affinity purification |
| 【Bioactive】： N0 |
| 【Tag】： With a 6×His tag at the N/C-terminus. |
| 【Concentration】： 1mg/ml by SDS-PAGE. |
Store:
| 【Reconstitution】： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| 【Storage】： Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year. |
| 【Formulation】： Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
Background:
The protein encoded by this gene is a member of the large DEAD-box protein family, that is defined by the presence of the conserved Asp-Glu-Ala-Asp (DEAD) motif, and has ATP-dependent RNA helicase activity.This protein has been reported to display a high level of RNA-independent ATPase activity, and unlike most DEAD-box helicases, the ATPase activity is thought to be stimulated by both RNA and DNA.This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm.Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export.In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication.Misregulation of this gene has been implicated in tumorigenesis.This gene has a paralog located in the nonrecombining region of the Y chromosome.Pseudogenes sharing similarity to both this gene and the DDX3Y paralog are found on chromosome 4 and the X chromosome.Alternative splicing results in multip
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