Summary:
Recombinant human MORF4L1 protein
Cat：P04202
| 【Derived From】： E.coli |
| 【Endotoxin】： Not measured |
| 【Amino Acid】： 1-324aa |
| 【Purity】： ≥85% by SDS-PAGE. |
| 【Name】： MORF4L1 |
| 【Full Name】： mortality factor 4 like 1 |
| 【Uniprot】： Q9UBU8 |
| 【Gene ID】： 10933 |
| 【Species Reactivity】： Human Mouse Rat (Gorilla) |
| 【Mol Mass】： 36kDa |
| 【Application】： Immunology research |
| 【Purification】： NI-NTA affinity purification |
| 【Bioactive】： N0 |
| 【Tag】： With a 6×His tag at the N/C-terminus. |
| 【Concentration】： 1mg/ml by SDS-PAGE. |
Store:
| 【Reconstitution】： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| 【Storage】： Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year. |
| 【Formulation】： Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
Background:
Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A.This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription.This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction； tumor suppressor mediated growth arrest and replicative senescence； apoptosis； and DNA repair.The NuA4 complex ATPase and helicase activities seem to be； at least in part； contributed by the association of RUVBL1 and RUVBL2 with EP400.NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage.Also component of the mSin3A complex which acts to repress transcription by deacetylation of nucleosomal histones.Required for homologous recombination repair (HRR) and resistanc
Verified picture
