Summary:
Recombinant human RNF34 protein
Cat：P04213
| 【Derived From】： E.coli |
| 【Endotoxin】： Not measured |
| 【Amino Acid】： 1-373aa |
| 【Purity】： ≥85% by SDS-PAGE. |
| 【Name】： RNF34 |
| 【Full Name】： ring finger protein 34 |
| 【Uniprot】： Q969K3 |
| 【Gene ID】： 80196 |
| 【Species Reactivity】： Human Mouse Rat (Gorilla Bovine) |
| 【Mol Mass】： 41kDa |
| 【Application】： Immunology research |
| 【Purification】： NI-NTA affinity purification |
| 【Bioactive】： N0 |
| 【Tag】： With a 6×His tag at the N/C-terminus. |
| 【Concentration】： 1mg/ml by SDS-PAGE. |
Store:
| 【Reconstitution】： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| 【Storage】： Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year. |
| 【Formulation】： Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
Background:
The protein encoded by this gene contains a RINF finger, a motif known to be involved in protein-protein and protein-DNA interactions.This protein interacts with DNAJA3/hTid-1, which is a DnaJ protein reported to function as a modulator of apoptosis.Overexpression of this gene in Hela cells was shown to confer the resistance to TNF-alpha induced apoptosis, suggesting an anti-apoptotic function of this protein.This protein can be cleaved by caspase-3 during the induction of apoptosis.This protein also targets p53 and phospho-p53 for degradation.Alternatively splicing results in multiple transcript variants encoding distinct isoforms.
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