Summary:
Recombinant human TMEM30A protein
Cat：P04217
| 【Derived From】： E.coli |
| 【Endotoxin】： Not measured |
| 【Amino Acid】： 68-267aa |
| 【Purity】： ≥85% by SDS-PAGE. |
| 【Name】： TMEM30A |
| 【Full Name】： transmembrane protein 30A |
| 【Uniprot】： Q9NV96 |
| 【Gene ID】： 55754 |
| 【Species Reactivity】： Human Mouse Rat (Gorilla Bovine Chicken) |
| 【Mol Mass】： 23kDa |
| 【Application】： Immunology research |
| 【Purification】： NI-NTA affinity purification |
| 【Bioactive】： N0 |
| 【Tag】： With a 6×His tag at the N/C-terminus. |
| 【Concentration】： 1mg/ml by SDS-PAGE. |
Store:
| 【Reconstitution】： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| 【Storage】： Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year. |
| 【Formulation】： Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
Background:
Accessory component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids.Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules.The beta subunit may assist in binding of the phospholipid substrate.Required for the proper folding, assembly and ER to Golgi exit of the ATP8A2:TMEM30A flippase complex.ATP8A2:TMEM30A may be involved in regulation of neurite outgrowth, and, reconstituted to liposomes, predomiminantly transports phosphatidylserine (PS) and to a lesser extent phosphatidylethanolamine (PE).The ATP8A1:TMEM30A flippase complex seems to play a role in regulation of cell migration probably involving flippase-mediated translocation of phosphatidylethanolamine (PE) at the plasma membrane.Required for the formation of the ATP8A2, ATP8B1 and ATP8B2 P-type A
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