Summary:
Recombinant human RBM4 protein
Cat：P04235
| 【Derived From】： E.coli |
| 【Endotoxin】： Not measured |
| 【Amino Acid】： 1-365aa |
| 【Purity】： ≥85% by SDS-PAGE. |
| 【Name】： RBM4 |
| 【Full Name】： RNA binding motif protein 4 |
| 【Uniprot】： Q9BWF3 |
| 【Gene ID】： 5936 |
| 【Species Reactivity】： Human Mouse Rat (Bovine Pig Rabbit) |
| 【Mol Mass】： 40kDa |
| 【Application】： Immunology research |
| 【Purification】： NI-NTA affinity purification |
| 【Bioactive】： N0 |
| 【Tag】： With a 6×His tag at the N/C-terminus. |
| 【Concentration】： 1mg/ml by SDS-PAGE. |
Store:
| 【Reconstitution】： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| 【Storage】： Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year. |
| 【Formulation】： Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
Background:
RNA-binding factor involved in multiple aspects of cellular processes like alternative splicing of pre-mRNA and translation regulation.Modulates alternative 5'-splice site and exon selection.Acts as a muscle cell differentiation-promoting factor.Activates exon skipping of the PTB pre-mRNA during muscle cell differentiation.Antagonizes the activity of the splicing factor PTBP1 to modulate muscle cell-specific exon selection of alpha tropomyosin.Binds to intronic pyrimidine-rich sequence of the TPM1 and MAPT pre-mRNAs.Required for the translational activation of PER1 mRNA in response to circadian clock.Binds directly to the 3'-UTR of the PER1 mRNA.Exerts a suppressive activity on Cap-dependent translation via binding to CU-rich responsive elements within the 3'UTR of mRNAs, a process increased under stress conditions or during myocytes differentiation.Recruits EIF4A1 to stimulate IRES-dependent translation initiation in respons to cellular stress.Associates to internal ribosome entry segment (IRES) in target mR
Verified picture
