Summary:
Recombinant human HERPUD1 protein
Cat：P04257
| 【Derived From】： E.coli |
| 【Endotoxin】： Not measured |
| 【Amino Acid】： 1-232aa |
| 【Purity】： ≥85% by SDS-PAGE. |
| 【Name】： HERPUD1 |
| 【Full Name】： homocysteine-inducible，endoplasmic reticulum stress-inducible，ubiquitin-like domain member 1 |
| 【Uniprot】： Q15011 |
| 【Gene ID】： 9709 |
| 【Species Reactivity】： Human Mouse (Gorilla) |
| 【Mol Mass】： 26kDa |
| 【Application】： Immunology research |
| 【Purification】： NI-NTA affinity purification |
| 【Bioactive】： No activity experimental data, to be verified. |
| 【Tag】： With a 6×His tag at the N/C-terminus. |
| 【Concentration】： 1mg/ml by SDS-PAGE. |
Store:
| 【Reconstitution】： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 10μg/ml. Dissolve the lyophilized protein in distilled water.) |
| 【Storage】： Reconstituted protein solution can be stored at 4-7℃ for 2-7 days， stored at < -20℃ for 1 year. |
| 【Formulation】： Powder: Lyophilized from a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
Background:
The accumulation of unfolded proteins in the endoplasmic reticulum (ER) triggers the ER stress response.This response includes the inhibition of translation to prevent further accumulation of unfolded proteins, the increased expression of proteins involved in polypeptide folding, known as the unfolded protein response (UPR), and the destruction of misfolded proteins by the ER-associated protein degradation (ERAD) system.This gene may play a role in both UPR and ERAD.Its expression is induced by UPR and it has an ER stress response element in its promoter region while the encoded protein has an N-terminal ubiquitin-like domain which may interact with the ERAD system.This protein has been shown to interact with presenilin proteins and to increase the level of amyloid-beta protein following its overexpression.Alternative splicing of this gene produces multiple transcript variants encoding different isoforms.The full-length nature of all transcript variants has not been determined.
Verified picture
