Summary:
Recombinant human PTENP1 protein
Cat：P04258
| 【Derived From】： E.coli |
| 【Endotoxin】： Not measured |
| 【Amino Acid】： 1-370aa |
| 【Purity】： ≥85% by SDS-PAGE. |
| 【Name】： PTENP1 |
| 【Full Name】： phosphatase and tensin homolog pseudogene 1 |
| 【Uniprot】： / |
| 【Gene ID】： 11191 |
| 【Species Reactivity】： / |
| 【Mol Mass】： 43kDa |
| 【Application】： Immunology research |
| 【Purification】： NI-NTA affinity purification |
| 【Bioactive】： N0 |
| 【Tag】： With a 6×His tag at the N/C-terminus. |
| 【Concentration】： 1mg/ml by SDS-PAGE. |
Store:
| 【Reconstitution】： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| 【Storage】： Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year. |
| 【Formulation】： Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
Background:
This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency.The protein encoded by this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase.It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases.Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates.It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway.The use of a non-canonical (CUG) upstream initiation site produces a longer isoform that initiates translation with a leucine, and is thought to be preferentially associated with the mitochondrial inner membrane.This longer isoform may help regulate energy metabolism in the mitochondria.A pseudogene of this gene is found on chromosome 9.Alternative splicing and the use of multi
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