Summary:
Recombinant human UBXN1 protein
Cat：P04262
| 【Derived From】： E.coli |
| 【Endotoxin】： Not measured |
| 【Amino Acid】： 1-312aa |
| 【Purity】： ≥85% by SDS-PAGE. |
| 【Name】： UBXN1 |
| 【Full Name】： UBX domain protein 1 |
| 【Uniprot】： Q04323 |
| 【Gene ID】： 51035 |
| 【Species Reactivity】： Human Mouse Rat (Bovine) |
| 【Mol Mass】： 34kDa |
| 【Application】： Immunology research |
| 【Purification】： NI-NTA affinity purification |
| 【Bioactive】： N0 |
| 【Tag】： With a 6×His tag at the N/C-terminus. |
| 【Concentration】： 1mg/ml by SDS-PAGE. |
Store:
| 【Reconstitution】： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| 【Storage】： Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year. |
| 【Formulation】： Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
Background:
Ubiquitin-binding protein that plays a role in the modulation of innate immune response.Blocks both the RIG-I-like receptors (RLR) and NF-kappa-B pathways.Following viral infection, UBXN1 is induced and recruited to the RLR component MAVS.In turn, interferes with MAVS oligomerization, and disrupts the MAVS/TRAF3/TRAF6 signalosome.This function probably serves as a brake to prevent excessive RLR signaling (PubMed:23545497).Interferes with the TNFalpha-triggered NF-kappa-B pathway by interacting with cellular inhibitors of apoptosis proteins (cIAPs) and thereby inhibiting their recruitment to TNFR1 (PubMed:25681446).Prevents also the activation of NF-kappa-B by associating with CUL1 and thus inhibiting NF-kappa-B inhibitor alpha/NFKBIA degradation that remains bound to NF-kappa-B (PubMed:28152074).Interacts with the BRCA1-BARD1 heterodimer and regulates its activity.Specifically binds 'Lys-6'-linked polyubiquitin chains.Interaction with autoubiquitinated BRCA1 leads to the inhibition of the E3 ubiquitin-protein
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