Summary:
Recombinant human CBS protein
Cat：P04276
| 【Derived From】： E.coli |
| 【Endotoxin】： Not measured |
| 【Amino Acid】： 1-342aa |
| 【Purity】： ≥85% by SDS-PAGE. |
| 【Name】： CBS |
| 【Full Name】： Cystathionine beta-synthase |
| 【Uniprot】： P35520 |
| 【Gene ID】： 875 |
| 【Species Reactivity】： Human Mouse Rat (Rabbit) |
| 【Mol Mass】： 38kDa |
| 【Application】： Immunology research |
| 【Purification】： NI-NTA affinity purification |
| 【Bioactive】： N0 |
| 【Tag】： With a 6×His tag at the N/C-terminus. |
| 【Concentration】： 1mg/ml by SDS-PAGE. |
Store:
| 【Reconstitution】： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| 【Storage】： Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year. |
| 【Formulation】： Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
Background:
The protein encoded by this gene acts as a homotetramer to catalyze the conversion of homocysteine to cystathionine, the first step in the transsulfuration pathway.The encoded protein is allosterically activated by adenosyl-methionine and uses pyridoxal phosphate as a cofactor.Defects in this gene can cause cystathionine beta-synthase deficiency (CBSD), which can lead to homocystinuria.This gene is a major contributor to cellular hydrogen sulfide production.Multiple alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Feb 2016]
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