Summary:
Recombinant human VPS11 protein
Cat：P04317
| 【Derived From】： E.coli |
| 【Endotoxin】： Not measured |
| 【Amino Acid】： 1-331aa |
| 【Purity】： ≥85% by SDS-PAGE. |
| 【Name】： VPS11 |
| 【Full Name】： vacuolar protein sorting 11 homolog (S. cerevisiae) |
| 【Uniprot】： Q9H270 |
| 【Gene ID】： 55823 |
| 【Species Reactivity】： Human Mouse (A.thaliana) |
| 【Mol Mass】： 36kDa |
| 【Application】： Immunology research |
| 【Purification】： NI-NTA affinity purification |
| 【Bioactive】： N0 |
| 【Tag】： With a 6×His tag at the N/C-terminus. |
| 【Concentration】： 1mg/ml by SDS-PAGE. |
Store:
| 【Reconstitution】： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| 【Storage】： Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year. |
| 【Formulation】： Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
Background:
Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including tHumane endocytic membrane transport and autopHumanagic patHumanways.Believed to act as a core component of tHumane putative HumanOPS and CORVET endosomal tetHumanering complexes wHumanicHuman are proposed to be involved in tHumane Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tetHumanering and docking events during SNARE-mediated membrane fusion.THumane HumanOPS complex is proposed to be recruited to Rab7 on tHumane late endosomal membrane and to regulate late endocytic, pHumanagocytic and autopHumanagic traffic towards lysosomes.THumane CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations.Required for fusion of endosomes and autopHumanagosomes witHuman lysosomes.Involved in cargo transport from early to late endosomes and required for tHumane transition from early to l
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