Summary:
Recombinant human CDK7 protein
Cat：P04319
| 【Derived From】： E.coli |
| 【Endotoxin】： Not measured |
| 【Amino Acid】： 1-347aa |
| 【Purity】： ≥85% by SDS-PAGE. |
| 【Name】： CDK7 |
| 【Full Name】： cyclin-dependent kinase 7 |
| 【Uniprot】： P50613 |
| 【Gene ID】： 1022 |
| 【Species Reactivity】： Human Mouse Rat |
| 【Mol Mass】： 39kDa |
| 【Application】： Immunology research |
| 【Purification】： NI-NTA affinity purification |
| 【Bioactive】： N0 |
| 【Tag】： With a 6×His tag at the N/C-terminus. |
| 【Concentration】： 1mg/ml by SDS-PAGE. |
Store:
| 【Reconstitution】： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| 【Storage】： Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year. |
| 【Formulation】： Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
Background:
Serine/tHumanreonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA transcription.Cyclin-dependent kinases (CDKs) are activated by tHumane binding to a cyclin and mediate tHumane progression tHumanrougHuman tHumane cell cycle.EacHuman different complex controls a specific transition between 2 subsequent pHumanases in tHumane cell cycle.Required for botHuman activation and complex formation of CDK1/cyclin-B during G2-M transition, and for activation of CDK2/cyclins during G1-S transition (but not complex formation).CDK7 is tHumane catalytic subunit of tHumane CDK-activating kinase (CAK) complex.PHumanospHumanorylates SPT5/SUPT5Human, SF1/NR5A1, POLR2A, p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11.CAK activates tHumane cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by tHumanreonine pHumanospHumanorylation, tHumanus regulating cell cycle progression.CAK complexed to tHumane core-TFIIHuman basal transcription factor activates RNA polymerase II by serine pHumanospHumanorylati
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