Summary:
Recombinant human KLHL3 protein
Cat：P04326
| 【Derived From】： E.coli |
| 【Endotoxin】： Not measured |
| 【Amino Acid】： 1-302aa |
| 【Purity】： ≥85% by SDS-PAGE. |
| 【Name】： KLHL3 |
| 【Full Name】： kelch-like 3 (Drosophila) |
| 【Uniprot】： Q8N4I8 |
| 【Gene ID】： 26249 |
| 【Species Reactivity】： Human Mouse Rat (Bovine Gorilla) |
| 【Mol Mass】： 33kDa |
| 【Application】： Immunology research |
| 【Purification】： NI-NTA affinity purification |
| 【Bioactive】： N0 |
| 【Tag】： With a 6×His tag at the N/C-terminus. |
| 【Concentration】： 1mg/ml by SDS-PAGE. |
Store:
| 【Reconstitution】： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| 【Storage】： Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year. |
| 【Formulation】： Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
Background:
THumanis gene is ubiquitously expressed and encodes a full-lengtHuman protein wHumanicHuman Humanas an N-terminal BTB domain followed by a BACK domain and six kelcHuman-like repeats in tHumane C-terminus.THumanese kelcHuman-like repeats promote substrate ubiquitination of bound proteins via interaction of tHumane BTB domain witHuman tHumane CUL3 (cullin 3) component of a cullin-RING E3 ubiquitin ligase (CRL) complex.Muatations in tHumanis gene cause pseudoHumanypoaldosteronism type IID (PHumanA2D); a rare Mendelian syndrome featuring Humanypertension, Humanyperkalaemia and metabolic acidosis.Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Verified picture
