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Recombinant human KCNMA1 protein

Cat:P05754

Summary:

【Derived From】: E.coli
【Endotoxin】: Not measured
【Amino Acid】: 1-85aa
【Purity】: ≥85% by SDS-PAGE.
【Name】: KCNMA1
【Full Name】: potassium large conductance calcium-activated channel,subfamily M,alpha member 1
【Uniprot】: Q12791
【Gene ID】: 3778
【Species Reactivity】: Human Mouse Rat (Bovine Chicken Dog Rabbit Pig)
【Mol Mass】: 8kDa
【Application】: Immunology research
【Purification】: NI-NTA affinity purification
【Bioactive】: N0
【Tag】: With a 6×His tag at the N/C-terminus.
【Concentration】: 1mg/ml by SDS-PAGE.

Store:

【Reconstitution】: Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.)
【Storage】: Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks, stored at < -20℃ for 1 year.
【Formulation】: Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0.

Background:

MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit, which is the product of this gene, and the modulatory beta subunit. Intracellular calcium regulates the physical association between the alpha and beta subunits. Alternatively spliced transcript variants encoding different isoforms have been identified.

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