Summary:
Recombinant human N-PAC protein
Cat：P05862
| 【Derived From】： E.coli |
| 【Endotoxin】： Not measured |
| 【Amino Acid】： 30-380aa |
| 【Purity】： ≥85% by SDS-PAGE. |
| 【Name】： N-PAC |
| 【Full Name】： cytokine-like nuclear factor n-pac |
| 【Uniprot】： Q49A26 |
| 【Gene ID】： 84656 |
| 【Species Reactivity】： Human Mouse Rat (Bovine Zebrafish Chicken Orangutan) |
| 【Mol Mass】： 38kDa |
| 【Application】： Immunology research |
| 【Purification】： NI-NTA affinity purification |
| 【Bioactive】： N0 |
| 【Tag】： With a 6×His tag at the N/C-terminus. |
| 【Concentration】： 1mg/ml by SDS-PAGE. |
Store:
| 【Reconstitution】： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| 【Storage】： Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year. |
| 【Formulation】： Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
Background:
Nucleosome-destabilizing factor that is recruited to genes during transcriptional activation (PubMed:29759984).Facilitates Pol II transcription through nucleosomes (PubMed:29759984).Binds DNA (in vitro) (PubMed:29759984).Recognizes and binds trimethylated 'Lys-36' of histone H3 (H3K36me3) (PubMed:20850016).Promotes KDM1B demethylase activity (PubMed:23260659).Stimulates the acetylation of 'Lys-56' of nucleosomal histone H3 (H3K56ac) by EP300 (PubMed:29759984).Regulates p38 MAP kinase activity by mediating stress activation of p38alpha/MAPK14 and specifically regulating MAPK14 signaling (PubMed:16352664).Indirectly promotes phosphorylation of MAPK14 and activation of ATF2 (PubMed:16352664).The phosphorylation of MAPK14 requires upstream activity of MAP2K4 and MAP2K6 (PubMed:16352664).Putative oxidoreductase (PubMed:23260659).
Verified picture
