Summary:
Recombinant human RNF166 protein
Cat：P06034
| 【Derived From】： E.coli |
| 【Endotoxin】： Not measured |
| 【Amino Acid】： 1-238aa |
| 【Purity】： ≥85% by SDS-PAGE. |
| 【Name】： RNF166 |
| 【Full Name】： ring finger protein 166 |
| 【Uniprot】： Q96A37 |
| 【Gene ID】： 115992 |
| 【Species Reactivity】： Human Mouse Rat (Chicken) |
| 【Mol Mass】： 26.1kDa |
| 【Application】： Immunology research |
| 【Purification】： NI-NTA affinity purification |
| 【Bioactive】： N0 |
| 【Tag】： With a 6×His tag at the N/C-terminus. |
| 【Concentration】： 1mg/ml by SDS-PAGE. |
Store:
| 【Reconstitution】： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| 【Storage】： Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year. |
| 【Formulation】： Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
Background:
E3 ubiquitin-protein ligase that promotes the ubiquitination of different substrates (PubMed:27880896).In turn, participates in different biological processes including interferon production or autophagy (PubMed:26456228, PubMed:27880896).Plays a role in the activation of RNA virus-induced interferon-beta production by promoting the ubiquitination of TRAF3 and TRAF6 (PubMed:26456228).Plays also a role in the early recruitment of autophagy adapters to bacteria (PubMed:27880896).Mediates 'Lys-29' and 'Lys-33'-linked ubiquitination of SQSTM1 leading to xenophagic targeting of bacteria and inhibition of their replication (PubMed:27880896).
Verified picture
