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CAS：25316-40-9
Molecular Formula：C27H29NO11·HCl
Molecular Weight：579.98
Appearance：Red powder
Storage：Store at 2-8℃，2 years
Purity：≥99%
Qty：
Size：
| Name | Doxorubicin |
| CAS | 25316-40-9 |
| Molecular Formula | C27H29NO11·HCl |
| Molecular Weight | 579.98 |
| Storage | Store at 2-8℃，2 years |
| Appearance | Red powder |
| Purity | ≥99% |
| Solubility | 10 mg/mL in Water |
| Unit | Bottle |
| Specification | 25mg 500mg |
Product Introduction:
Doxorubicin, an anthracycline antibiotic, inhibits the synthesis of DNA and RNA in mammals and is also a very potent antitumor agent (1,2). Doxorubicin binds to nucleic acids by embedding DNA double helices and stable topoisomerase II cleavage complexes, resulting in strand breakage of DNA at specific doxorubicin induced sites (3). In human breast cancer cells (MCF7), doxorubicin inhibits DNA synthesis in a dose-dependent manner, consistent with growth inhibition (4). The researchers also found that doxorubicin can effectively inhibit human DNA topoisomerase I (5).
Doxorubicin provided is freeze-dried powder. For a 10 mM concentration storage solution, 860 μl DMSO was added to 5mg of freeze-dried powder. The working concentration and treatment time are determined according to the desired effect, generally 0.1-5μM, for 12-24 hours of treatment.
Use and synthesis method:
Antitumor antibiotic, has doxorubicin effect on cardiac mitochondrial DNA. Inhibitor of reverse phase transcriptase and RNA polymerase, immunosuppressant; It can be inserted into a DNA strand.
Solubility:
Soluble in DMSO (100 mg/ml) and slightly hot water (10 mg/ml), insoluble in ethanol.
Note :
(1) For cell experiments, after dissolution, disposable needle filter must be used to remove bacteria.
(2) For your safety and health, please wear a lab coat and wear disposable gloves.
Note：Product information may be optimized and upgraded. Please refer to the actual label information for accuracy.
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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