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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Neuronal Signal Pathway > Duloxetine HydrochlorideCAS：136434-34-9
Molecular Formula：C18H20ClNOS
Molecular Weight：333.88
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 136434-34-9 |
| Name | Duloxetine Hydrochloride |
| Molecular Formula | C18H20ClNOS |
| Molecular Weight | 333.88 |
| Solubility | Soluble in DMSO ≥5mg/mL |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD06407958 |
| SMILES | CNCC[C@@H](C1=CC=CS1)OC2=CC=CC3=CC=CC=C32.Cl |
| InChIKey | BFFSMCNJSOPUAY-LMOVPXPDSA-N |
| InChI | InChI=1S/C18H19NOS.ClH/c1-19-12-11-17(18-10-5-13-21-18)20-16-9-4-7-14-6-2-3-8-15(14)16;/h2-10，13，17，19H，11-12H2，1H3;1H/t17-;/m0./s1 |
| PubChem CID | 60834 |
| Target Point | Serotonin Transporter |
| Passage | Neuronal Signaling |
| Background | It is a serotonin-norepinephrine reuptake inhibitor (SNRI) that can be used in studies of generalized anxiety disorder. |
| Biological Activity | Duloxetine hydrochloride是一种血清素-去甲肾上腺素再摄取抑制剂 (SNRI)，其 Ki 值为 4.6 nM，用于治疗重度抑郁障碍和广泛性焦虑障碍 (GAD)。[1-2] |
| Data Literature Source | [1]. Redrobe JP，et al. Dose-dependent noradrenergic and serotonergic properties of venlafaxine in animal models indicative of antidepressant activity. Psychopharmacology (Berl). 1998 Jul;138(1): 1-8. [2]. Deecher DC，et al. Desvenlafaxine succinate: A new serotonin and norepinephrine reuptake inhibitor. J Pharmacol Exp Ther. 2006 Aug;318(2): 657-65. |
| Unit | Bottle |
| Specification | 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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