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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Neuronal Signal Pathway > Eletriptan HydrobromideCAS：177834-92-3
Molecular Formula：C22H27BrN2O2S
Molecular Weight：463.43
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Off-white to light yellow Solid
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| CAS | 177834-92-3 |
| Name | Eletriptan Hydrobromide |
| Molecular Formula | C22H27BrN2O2S |
| Molecular Weight | 463.43 |
| Solubility | Soluble in DMSO(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | Off-white to light yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD08141806 |
| SMILES | CN1CCCC1CC2=CNC3=C2C=C(C=C3)CCS(=O)(=O)C4=CC=CC=C4.Br |
| InChIKey | UTINOWOSWSPFLJ-FSRHSHDFSA-N |
| InChI | InChI=1S/C22H26N2O2S.BrH/c1-24-12-5-6-19(24)15-18-16-23-22-10-9-17(14-21(18)22)11-13-27(25，26)20-7-3-2-4-8-20;/h2-4，7-10，14，16，19，23H，5-6，11-13，15H2，1H3;1H/t19-;/m1./s1 |
| PubChem CID | 656631 |
| Target Point | 5-HT Receptor |
| Passage | Neuronal Signaling；GPCR & G Protein |
| Background | It is a selective 5-HT1B and 5-HT1D receptor agonist |
| Biological Activity | Eletriptan是一种口服活性激动剂，对 5- 羟基三尖杉酯胺 1B/1D 受体具有特异性亲和力，Ki值分别为0.92 nM和3.14 nM。[1] |
| Data Literature Source | [1]. Napier C，et al. Characterisation of the 5-HT receptor binding profile of eletriptan and kinetics of [3H]eletriptan binding at human 5-HT1B and 5-HT1D receptors. Eur J Pharmacol. 1999 Mar 5;368(2-3): 259-68. [2]. MaassenVanDenBrink A，et al. Craniovascular selectivity of eletriptan and sumatriptan in human isolated blood vessels. Neurology. 2000 Nov 28;55(10): 1524-30. [3]. Gupta P，et al. The in vivo pharmacological profile of eletriptan (UK-116，044): a potent and novel 5-HT(1B/1D) receptor agonist. Eur J Pharmacol. 2000 Jun 9;398(1): 73-81. [4]. Hoskin KL，et al. The 5-hydroxytryptamine1B/1D/1F receptor agonists eletriptan and naratriptan inhibit trigeminovascular input to the nucleus tractus solitarius in the cat. Brain Res. 2004 Feb 13;998(1): 91-9. |
| Unit | Bottle |
| Specification | 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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