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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Membrane Transporter & Ion Channel > Esomeprazole SodiumCAS：161796-78-7
Molecular Formula：C17H18N3NaO3S
Molecular Weight：367.4
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 161796-78-7 |
| Name | Esomeprazole Sodium |
| Molecular Formula | C17H18N3NaO3S |
| Molecular Weight | 367.4 |
| Solubility | Soluble in DMSO ≥5mg/mL |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD07802816 |
| SMILES | CC1=CN=C(C(=C1OC)C)CS(=O)C2=NC3=C([N-]2)C=C(C=C3)OC.[Na+] |
| InChIKey | RYXPMWYHEBGTRV-JIDHJSLPSA-N |
| InChI | InChI=1S/C17H18N3O3S.Na/c1-10-8-18-15(11(2)16(10)23-4)9-24(21)17-19-13-6-5-12(22-3)7-14(13)20-17;/h5-8H，9H2，1-4H3;/q-1;+1/t24-;/m0./s1 |
| PubChem CID | 46853837 |
| Target Point | Proton Pump |
| Passage | Membrane Transporter&Ion Channel |
| Background | It is an effective proton pump inhibitor, which can reduce acid secretion by inhibiting H+/K+ ATPase in gastric parietal cells. |
| Biological Activity | Esomeprazole Sodium是一种强效口服活性质子泵抑制剂。通过抑制胃顶叶细胞中的 H+、K+-ATPase 减少胃酸分泌，是一种外泌体抑制剂，通过抑制 V-H+-ATP 酶阻断外泌体的释放，具有对症治疗胃食管反流病的研究潜力。[1-4] |
| Data Literature Source | [1]. Goh W，et al. Use of proton pump inhibitors as adjunct treatment for triple-negative breast cancers. An introductory study. J Pharm Pharm Sci. 2014;17(3): 439-46. [2]. Nelson C，et al. Therapeutic Efficacy of Esomeprazole in Cotton Smoke-Induced Lung Injury Model. Front Pharmacol. 2017 Jan 26;8: 16. [3]. Johnson TJ，Hedge DD. Esomeprazole: a clinical review. Am J Health Syst Pharm. 2002 Jul 15;59(14): 1333-9. [4]. Zhang H，et al. Advances in the discovery of exosome inhibitors in cancer. J Enzyme Inhib Med Chem. 2020 Dec;35(1): 1322-1330. |
| Unit | Bottle |
| Specification | 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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