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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Membrane Transporter & Ion Channel > EthosuximideCAS：77-67-8
Molecular Formula：C7H11NO2
Molecular Weight：141.17
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 77-67-8 |
| Name | Ethosuximide |
| Molecular Formula | C7H11NO2 |
| Molecular Weight | 141.17 |
| Solubility | Soluble in Water/DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 201-048-7 |
| MDL | MFCD00072123 |
| SMILES | CCC1(CC(=O)NC1=O)C |
| InChIKey | HAPOVYFOVVWLRS-UHFFFAOYSA-N |
| InChI | InChI=1S/C7H11NO2/c1-3-7(2)4-5(9)8-6(7)10/h3-4H2，1-2H3，(H，8，9，10) |
| PubChem CID | 3291 |
| Target Point | Calcium Channel |
| Passage | Membrane Transporter&Ion Channel |
| Background | It is a calcium channel blocker with antiepileptic activity. |
| Biological Activity | Ethosuximide是一种广泛使用的抗癫痫药，它能改善多种神经退行性疾病模型的表型，并能阻断低电压激活的 T 型钙通道。[1-4] |
| Data Literature Source | [1]. Chen X，et al. Ethosuximide ameliorates neurodegenerative disease phenotypes by modulating DAF-16/FOXO target gene expression. Mol Neurodegener. 2015 Sep 29;10: 51. [2]. Collins JJ，et al. The anticonvulsant ethosuximide disrupts sensory function to extend C. elegans lifespan. PLoS Genet. 2008 Oct;4(10): e1000230. [3]. Tiwari SK，et al. Ethosuximide Induces Hippocampal Neurogenesis and Reverses Cognitive Deficits in an Amyloid-β Toxin-induced Alzheimer Rat Model via the Phosphatidylinositol 3-Kinase (PI3K)/Akt/Wnt/β-Catenin Pathway. J Biol Chem. 2015 Nov 20;290(47): 28540-28558. [4]. Coulter DA，et al. Characterization of ethosuximide reduction of low-threshold calcium current in thalamic neurons. Ann Neurol. 1989 Jun;25(6): 582-93. |
| Unit | Bottle |
| Specification | 200mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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