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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Neuronal Signal Pathway > Homatropine MethylbromideCAS：80-49-9
Molecular Formula：C17H24BrNO3
Molecular Weight：370.28
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 80-49-9 |
| Name | Homatropine Methylbromide |
| Molecular Formula | C17H24BrNO3 |
| Molecular Weight | 370.28 |
| Solubility | Soluble in Water/DMSO ≥2mg/mL |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 201-284-0 |
| MDL | MFCD00050292 |
| SMILES | C[N+]1(C2CCC1CC(C2)OC(=O)C(C3=CC=CC=C3)O)C.[Br-] |
| InChIKey | FUFVKLQESJNNAN-ZZJGABIISA-M |
| InChI | InChI=1S/C17H24NO3.BrH/c1-18(2)13-8-9-14(18)11-15(10-13)21-17(20)16(19)12-6-4-3-5-7-12;/h3-7，13-16，19H，8-11H2，1-2H3;1H/q+1;/p-1/t13-，14+，15?，16?; |
| PubChem CID | 10429215 |
| Target Point | mAChR |
| Passage | Neuronal Signaling;GPCR & G Protein |
| Background | It is a muscarinic receptor AChR antagonist. |
| Biological Activity | Homatropine methbromide 是毒蕈碱 AChR 拮抗剂，可抑制 WKY-E 和 SHR-E 的内皮和平滑肌毒蕈碱受体，IC50 分别为 162.5 nM 和 170.3 nM。[1] |
| IC50 | WKY-E: 162.5nM(IC50);SHR-E: 170.4nM(IC50)[1] |
| Data Literature Source | [1]. Sim MK，et al. Muscarinic receptors in the aortae of normo- and hypertensive rats: a binding study. Clin Exp Hypertens. 1993 Mar;15(2):409-21. [2]. Leung E，et al. Modification by hexamethonium of the muscarinic receptors blocking activity of pancuronium and homatropine in isolated tissues of the guinea-pig. Eur J Pharmacol. 1982 May 7;80(1):11-7. [3]. Gilani SA，et al. Interaction of himbacine with carbachol at muscarinic receptors of heart and smooth muscle. Arch Int Pharmacodyn Ther. 1987 Nov;290(1):46-53. [4]. Bryant SM，et al. Intramuscular ophthalmic homatropine vs. atropine to prevent lethality in rates with dichlorvos poisoning. J Med Toxicol. 2006 Dec;2(4):156-9. [5]. Cramer MB，et al. Rectal absorption of homatropine [14C]methylbromide in the rat. J Pharm Pharmacol. 1978 May;30(5):284-6. |
| Unit | Bottle |
| Specification | 25mg 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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