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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Neuronal Signal Pathway > Nefazodone HydrochlorideCAS：82752-99-6
Molecular Formula：C25H33Cl2N5O2
Molecular Weight：506.47
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 82752-99-6 |
| Name | Nefazodone Hydrochloride |
| Molecular Formula | C25H33Cl2N5O2 |
| Molecular Weight | 506.47 |
| Solubility | Soluble in DMSO(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00935760 |
| SMILES | CCC1=NN(C(=O)N1CCOC2=CC=CC=C2)CCCN3CCN(CC3)C4=CC(=CC=C4)Cl.Cl |
| InChIKey | DYCKFEBIOUQECE-UHFFFAOYSA-N |
| InChI | InChI=1S/C25H32ClN5O2.ClH/c1-2-24-27-31(25(32)30(24)18-19-33-23-10-4-3-5-11-23)13-7-12-28-14-16-29(17-15-28)22-9-6-8-21(26)20-22;/h3-6，8-11，20H，2，7，12-19H2，1H3;1H |
| PubChem CID | 54911 |
| Target Point | 5-HT Receptor |
| Passage | Neuronal Signaling；GPCR & G Protein |
| Background | It is a potent and selective 5HT2A antagonist with moderate inhibition of 5-HT and norepinephrine uptake. It has antidepressant activity. |
| Biological Activity | Nefazodone Hydrochloride 是一种强效、选择性的 5HT2A 拮抗剂（Ki=5.8 nM），对 5-HT 和去甲肾上腺素的摄取有中度抑制作用（IC50 分别为 290 nM 和 300 nM）。也是一种苯丙哌嗪类抗抑郁药，α-肾上腺素能阻断活性较低。[1-2] |
| Data Literature Source | [1]. Pullar IA，et al. LY367265，an inhibitor of the 5-hydroxytryptamine transporter and 5-hydroxytryptamine(2A) receptor antagonist: a comparison with the antidepressant，nefazodone. Eur J Pharmacol. 2000 Oct 27;407(1-2):39-46. [2]. Ellingrod VL，et al. Nefazodone: a new antidepressant. Am J Health Syst Pharm. 1995 Dec 15;52(24):2799-812. |
| Unit | Bottle |
| Specification | 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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