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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Neuronal Signal Pathway > NefiracetamCAS：77191-36-7
Molecular Formula：C14H18N2O2
Molecular Weight：246.3
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 77191-36-7 |
| Name | Nefiracetam |
| Molecular Formula | C14H18N2O2 |
| Molecular Weight | 246.3 |
| Solubility | Soluble in DMSO ≥5mg/mL |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 636-080-4 |
| MDL | MFCD00209882 |
| SMILES | CC1=C(C(=CC=C1)C)NC(=O)CN2CCCC2=O |
| InChIKey | NGHTXZCKLWZPGK-UHFFFAOYSA-N |
| InChI | InChI=1S/C14H18N2O2/c1-10-5-3-6-11(2)14(10)15-12(17)9-16-8-4-7-13(16)18/h3，5-6H，4，7-9H2，1-2H3，(H，15，17) |
| PubChem CID | 71157 |
| Target Point | GABA Receptor |
| Passage | Neuronal Signaling;GPCR & G Protein |
| Background | It is a nervous system enhancer of GABAergic, choline and monoamine. |
| Biological Activity | Nefiracetam是一种 GABA 能、胆碱能和单胺类神经元系统增强剂，能增强 Ro 5-4864 诱导的惊厥。[1] |
| Data Literature Source | [1]. Shiotani T，et al. Anticonvulsant actions of nefiracetam on epileptic EL mice and their relation to peripheral-type benzodiazepine receptors. Brain Res. 2000 Mar 24;859(2):255-61. [2]. Yoshii M，et al. Enhancement of neuronal calcium channel currents by the nootropic agent，nefiracetam (DM-9384)，in NG108-15 cells. Brain Res. 1994 Apr 11;642(1-2):123-31. [3]. Nishizaki T，et al. Nefiracetam modulates acetylcholine receptor currents via two different signal transduction pathways. Mol Pharmacol. 1998 Jan;53(1):1-5. [4]. Nishizaki T，et al. The anti-dementia drug nefiracetam facilitates hippocampal synaptic transmission by functionally targeting presynaptic nicotinic ACh receptors. Brain Res Mol Brain Res. 2000 Aug 14;80(1):53-62. [5]. Sakurai T，et al. Effects of N-(2，6-dimethylphenyl)-2-(2-oxo-1-pyrrolidinyl)acetamide (DM-9384) on learning and memory in rats. Jpn J Pharmacol. 1989 May;50(1):47-53. |
| Unit | Bottle |
| Specification | 50mg 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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