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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Neuronal Signal Pathway > OndansetronCAS：99614-02-5
Molecular Formula：C18H19N3O
Molecular Weight：293.36
Storage：Powder:2-8℃，2 years
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 99614-02-5 |
| Name | Ondansetron |
| Molecular Formula | C18H19N3O |
| Molecular Weight | 293.36 |
| Solubility | Soluble in Water/DMSO ＜ 1mg/mL |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years |
| MDL | MFCD00833882 |
| SMILES | CC1=NC=CN1CC2CCC3=C(C2=O)C4=CC=CC=C4N3C |
| InChIKey | FELGMEQIXOGIFQ-UHFFFAOYSA-N |
| InChI | InChI=1S/C18H19N3O/c1-12-19-9-10-21(12)11-13-7-8-16-17(18(13)22)14-5-3-4-6-15(14)20(16)2/h3-6，9-10，13H，7-8，11H2，1-2H3 |
| PubChem CID | 4595 |
| Target Point | 5-HT Receptor |
| Passage | Neuronal Signaling；GPCR & G Protein |
| Background | It is a 5-HT3 receptor antagonist. |
| Biological Activity | Ondansetron 是一种血清素 5-HT3 受体拮抗剂，主要用于止吐（治疗恶心和呕吐），通常在化疗后使用。 |
| Data Literature Source | [1]. Brown AM，et al. Ion permeation and conduction in a human recombinant 5-HT3 receptor subunit (h5-HT3A). J Physiol. 1998 Mar 15;507 ( Pt 3)(Pt 3):653-65. [2]. Barann M，et al. Recombinant human 5-HT3A receptors in outside-out patches of HEK 293 cells: basic properties and barbiturate effects. Naunyn Schmiedebergs Arch Pharmacol. 2000 Sep;362(3):255-65. [3]. Wildeboer KM，et al. Ondansetron results in improved auditory gating in DBA/2 mice through a cholinergic mechanism. Brain Res. 2009 Dec 1;1300:41-50. doi: 10.1016/j.brainres.2009.08.075. Epub 2009 Sep 1. [4]. Khedhaier A，et al. Circadian rhythms in toxic effects of the serotonin antagonist ondansetron in mice. Chronobiol Int. 2003 Nov;20(6):1103-16. [5]. Umathe SN，et al. The 5-HT3 receptor antagonist，ondansetron，blocks the development and expression of ethanol-induced locomotor sensitization in mice. Behav Pharmacol. 2009 Feb;20(1):78-83. |
| Unit | Bottle |
| Specification | 50mg 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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