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My CartCAS：500-92-5
Molecular Formula：C11H16ClN5
Molecular Weight：253.73
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 500-92-5 |
| Name | Proguanil |
| Molecular Formula | C11H16ClN5 |
| Molecular Weight | 253.73 |
| Solubility | Soluble in DMSO(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 207-915-6 |
| MDL | MFCD00133609 |
| SMILES | CC(C)N=C(N)N=C(N)NC1=CC=C(C=C1)Cl |
| InChIKey | SSOLNOMRVKKSON-UHFFFAOYSA-N |
| InChI | InChI=1S/C11H16ClN5/c1-7(2)15-10(13)17-11(14)16-9-5-3-8(12)4-6-9/h3-7H，1-2H3，(H5，13，14，15，16，17) |
| PubChem CID | 6178111 |
| Target Point | Parasite |
| Passage | Anti-infection |
| Background | Proguanil inhibits the parasites dihydrofolate reductase, preventing the synthesis of purines and pyrimidines. |
| Biological Activity | Proguanil 是一种抗疟原药，经代谢可生成活性代谢物 Cycloguanil，也是一种二氢叶酸还原酶（DHFR）抑制剂。[1-2] |
| Data Literature Source | [1]. Pudney M，et al. Atovaquone and proguanil hydrochloride: a review of nonclinical studies. J Travel Med. 1999 May;6 Suppl 1:S8-12. [2]. Srivastava IK，et al. A mechanism for the synergistic antimalarial action of atovaquone and proguanil. Antimicrob Agents Chemother. 1999 Jun;43(6):1334-9. [3]. Lochner M，et al. The antimalarial drug proguanil is an antagonist at 5-HT3 receptors. J Pharmacol Exp Ther. 2014 Dec;351(3):674-84. [4]. Stephen AO，et al. Prolonged administration of proguanil induces reproductive toxicity in male rats. J Toxicol Sci. 2011 Oct;36(5):587-99. [5]. Iguchi A，et al. The in vitro interactions and in vivo efficacy of atovaquone and proguanil against Babesia gibsoni infection in dogs. Vet Parasitol. 2013 Nov 8;197(3-4):527-33. |
| Unit | Bottle |
| Specification | 10mg 25mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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