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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Neuronal Signal Pathway > Quinolinic AcidCAS：89-00-9
Molecular Formula：C7H5NO4
Molecular Weight：167.12
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 89-00-9 |
| Name | Quinolinic Acid |
| Molecular Formula | C7H5NO4 |
| Molecular Weight | 167.12 |
| Solubility | Soluble in DMSO(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 201-874-8 |
| MDL | MFCD00006295 |
| SMILES | C1=CC(=C(N=C1)C(=O)O)C(=O)O |
| InChIKey | GJAWHXHKYYXBSV-UHFFFAOYSA-N |
| InChI | InChI=1S/C7H5NO4/c9-6(10)4-2-1-3-8-5(4)7(11)12/h1-3H，(H，9，10)(H，11，12) |
| PubChem CID | 1066 |
| Target Point | NMDAR |
| Passage | Membrane Transporter&Ion Channel;Neuronal Signaling |
| Background | It is an N-methyl-D-aspartic acid receptor agonist. |
| Biological Activity | Quinolinic Acid 是一种内源性 N-甲基-D-天冬氨酸受体激动剂，由 L-色氨酸通过犬尿氨酸途径合成，有可能介导 N-甲基-D-天冬氨酸神经元损伤和功能障碍。[1] |
| Data Literature Source | [1]. Heyes MP，et al. Quinolinic acid and kynurenine pathway metabolism in inflammatory and non-inflammatory neurological disease. Brain. 1992 Oct;115 ( Pt 5):1249-73. [2]. Jang S，et al. Neuroprotective effects of (-)-epigallocatechin-3-gallate against quinolinic acid-induced excitotoxicity via PI3K pathway and NO inhibition. Brain Res. 2010 Feb 8;1313:25-33. |
| Unit | Bottle |
| Specification | 250mg 500mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
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FAR591 promotes the pathogenesis and progression of SONFH by regulating Fos expression to mediate the apoptosis of bone microvascular endothelial cells
Click to check >>Author：Zhang Fei, Wei Lei, Wang Lei, Wang Tao, Xie Zhihong, Luo Hong, Li Fanchao, Zhang Jian, Dong Wentao, Liu Gang, Kang Qinglin, Zhu Xuesong, Peng Wuxun
IF：13.3620
Publish_to：Bone Research
PMID：37217464
FAR591 promotes the pathogenesis and progression of SONFH by regulating Fos expression to mediate the apoptosis of bone microvascular endothelial cells
Click to check >>Author：Zhang Fei; Wei Lei; Wang Lei; Wang Tao; Xie Zhihon
IF：12.7000
Publish_to：Bone Research
PMID：37217464
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