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My CartCAS：22662-39-1
Molecular Formula：C19H11Cl2I2NO3
Molecular Weight：626.01
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 22662-39-1 |
| Name | Rafoxanide |
| Molecular Formula | C19H11Cl2I2NO3 |
| Molecular Weight | 626.01 |
| Solubility | Soluble in DMSO(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 245-148-9 |
| MDL | MFCD00682899 |
| SMILES | C1=CC(=CC=C1OC2=C(C=C(C=C2)NC(=O)C3=C(C(=CC(=C3)I)I)O)Cl)Cl |
| InChIKey | NEMNPWINWMHUMR-UHFFFAOYSA-N |
| InChI | InChI=1S/C19H11Cl2I2NO3/c20-10-1-4-13(5-2-10)27-17-6-3-12(9-15(17)21)24-19(26)14-7-11(22)8-16(23)18(14)25/h1-9，25H，(H，24，26) |
| PubChem CID | 31475 |
| Target Point | Parasite |
| Passage | Anti-infection |
| Background | Rafoxanide has antiparasitic activity and interferes with energy metabolism in fluke by uncoupling oxidative phosphorylation. |
| Biological Activity | Rafoxanide 是一种具有抗寄生虫活性的口服活性卤代水杨酰苯胺制剂，可用于控制绵羊和牛的血吸虫、法氏囊虫以及绵羊的卵黄囊虫，通过解除氧化磷酸化的耦合作用，干扰吸虫的能量代谢，能消灭反刍动物体内 91-99% 的成熟吸虫和 50-90% 的幼年吸虫。[1-3] |
| Data Literature Source | [1]. El-Banna HA，et al. Comparative pharmacokinetics of ivermectin alone and a novel formulation of ivermectin and rafoxanide in calves and sheep. Parasitol Res. 2008 May;102(6):1337-42. [2]. van Wyk JA，et al. Two field strains of Haemonchus contortus resistant to rafoxanide. Onderstepoort J Vet Res. 1987 Jun;54(2):143-6. [3]. Sharma，S.et al. Salicylanilides. Approaches to Design and Synthesis of Antiparasitic Drugs，239–257. doi:10.1016/s0165-7208(97)80031-1. |
| Unit | Bottle |
| Specification | 500mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
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3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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