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My Cart> Small Molecule Compounds > Anti-Infection > Anti-Bacterial > Spectinomycin DihydrochlorideCAS：21736-83-4
Molecular Formula：C14H26Cl2N2O7
Molecular Weight：405.27
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 21736-83-4 |
| Name | Spectinomycin Dihydrochloride |
| Molecular Formula | C14H26Cl2N2O7 |
| Molecular Weight | 405.27 |
| Solubility | Soluble in Water ≥5mg/mL |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 244-554-3 |
| MDL | MFCD00070403 |
| SMILES | CC1CC(=O)C2(C(O1)OC3C(C(C(C(C3O2)NC)O)NC)O)O.Cl.Cl |
| InChIKey | FOGDPGQSHLLYIK-XYQGXRRISA-N |
| InChI | InChI=1S/C14H24N2O7.2ClH/c1-5-4-6(17)14(20)13(21-5)22-12-10(19)7(15-2)9(18)8(16-3)11(12)23-14;;/h5，7-13，15-16，18-20H，4H2，1-3H3;2*1H/t5-，7-，8+，9+，10+，11-，12-，13+，14+;;/m1../s1 |
| PubChem CID | 64740 |
| Target Point | Bacterial |
| Passage | Anti-infection |
| Background | It is an antibiotic that works by binding to the 30S subunit of the bacterial ribosome and interfering with protein synthesis. |
| Biological Activity | Spectinomycin Dihydrochloride 是一种广谱抗生素，可抑制多种革兰氏阳性和革兰氏阴性菌的生长，还是td内含子RNA的非竞争性抑制剂，其Ki值为7.2 mM，通过选择性地靶向细菌核糖体并中断蛋白质合成而发挥作用。[1-4] |
| Data Literature Source | [1]. Park IK，et al. Spectinomycin inhibits the self-splicing of the group 1 intron RNA. Biochem Biophys Res Commun. 2000 Mar 16;269(2):574-9. [2]. Khan EA，et al. Safety evaluation study of lincomycin and spectinomycin hydrochloride intramuscular injection in chickens. Toxicol Rep. 2022 Jan 29;9:204-209. [3]. Madhura DB，Lee R，Meibohm B. Pharmacokinetic profile of spectinomycin in rats. Pharmazie. 2013 Aug;68(8):675-6. [4]. Brink MF，et al. Spectinomycin interacts specifically with the residues G1064 and C1192 in 16S rRNA，thereby potentially freezing this molecule into an inactive conformation. Nucleic Acids Res. 1994 Feb 11;22(3):325-31. |
| Unit | Bottle |
| Specification | 500mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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Unlocking the potentials of cyanobacterial photosynthesis for directly converting carbon dioxide into glucose
Click to check >>Author：Zhang Shanshan，Sun Jiahui，Feng Dandan，Sun Huili，Cu
IF：16.6000
Publish_to：Nature Communications
PMID：37296173
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