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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Endocrinology & Hormones > DoxazosinCAS：74191-85-8
Molecular Formula：C23H25N5O5
Molecular Weight：451.48
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Solid
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| CAS | 74191-85-8 |
| Name | Doxazosin |
| Molecular Formula | C23H25N5O5 |
| Molecular Weight | 451.48 |
| Solubility | Soluble in DMSO(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00800482 |
| SMILES | COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4COC5=CC=CC=C5O4)N)OC |
| InChIKey | RUZYUOTYCVRMRZ-UHFFFAOYSA-N |
| InChI | InChI=1S/C23H25N5O5/c1-30-18-11-14-15(12-19(18)31-2)25-23(26-21(14)24)28-9-7-27(8-10-28)22(29)20-13-32-16-5-3-4-6-17(16)33-20/h3-6，11-12，20H，7-10，13H2，1-2H3，(H2，24，25，26) |
| PubChem CID | 3157 |
| Target Point | Adrenergic Receptor |
| Passage | Endocrinology & Hormones;GPCR & G Protein；Neuronal Signaling |
| Background | Doxazosin, a quinazoline derivative, selectively antagonizes the post-synaptic α1-adrenergic receptors. |
| Biological Activity | Doxazosin 是一种喹唑啉衍生物，是一种长效的α1-肾上腺素受体抑制剂，被广泛用于治疗良性前列腺增生和高血压。[1-3] |
| Data Literature Source | [1]. Sun JA，et al. Stereoselective binding of doxazosin enantiomers to plasma proteins from rats，dogs and humans in vitro. Acta Pharmacol Sin. 2013 Dec;34(12):1568-74. [2]. D'Eletto RD，et al. Effect of doxazosin on cholesterol synthesis in cell culture. J Cardiovasc Pharmacol. 1989;13 Suppl 2:S1-4; discussion S4. [3]. Miura Y，et al. Doxazosin: a newly developed，selective alpha 1-inhibitor in the management of patients with pheochromocytoma. Am Heart J. 1988 Dec;116(6 Pt 2):1785-9. |
| Unit | Bottle |
| Specification | 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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