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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Membrane Transporter & Ion Channel > A-317491CAS：475205-49-3
Molecular Formula：C33H27NO8
Molecular Weight：565.57
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Solid
Qty：
Size：
| CAS | 475205-49-3 |
| Name | A-317491 |
| Molecular Formula | C33H27NO8 |
| Molecular Weight | 565.57 |
| Solubility | Soluble in DMSO ≥5mg/mL |
| Purity | ≥98% |
| Appearance | Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD28044314 |
| SMILES | C1CC(C2=CC=CC=C2C1)N(CC3=CC(=CC=C3)OC4=CC=CC=C4)C(=O)C5=CC(=C(C=C5C(=O)O)C(=O)O)C(=O)O |
| InChIKey | VQGBOYBIENNKMI-LJAQVGFWSA-N |
| InChI | InChI=1S/C33H27NO8/c35-30(25-17-27(32(38)39)28(33(40)41)18-26(25)31(36)37)34(29-15-7-10-21-9-4-5-14-24(21)29)19-20-8-6-13-23(16-20)42-22-11-2-1-3-12-22/h1-6，8-9，11-14，16-18，29H，7，10，15，19H2，(H，36，37)(H，38，39)(H，40，41)/t29-/m0/s1 |
| PubChem CID | 9829395 |
| Target Point | P2X Receptor |
| Passage | Membrane Transporter&Ion Channel |
| Background | A-317491 is A nonnucleotide P2X3 and P2X2/3 receptor antagonist that inhibits calcium flow mediated by it. |
| Biological Activity | A-317491 是一种新型的 P2X3 和 P2X2/3 受体激活非核苷酸拮抗剂，对 hP2X3、rP2X3、hP2X2/3 和 rP2X2/3 的 Kis 分别为 22、22、9 和 92 nM。对其他 P2 受体和其他神经递质受体、离子通道和酶具有高度选择性（IC50>10 μM）。通过阻断 P2X3 和 P2X2/3 受体介导的钙通量，减轻炎症性疼痛和神经病理性疼痛。[1-2] |
| Data Literature Source | [1]. Jarvis MF，et al. A-317491，a novel potent and selective non-nucleotide antagonist of P2X3 and P2X2/3 receptors，reduces chronic inflammatory and neuropathic pain in the rat. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):17179-84. [2]. Wu G，et al. A-317491，a selective P2X3/P2X2/3 receptor antagonist，reverses inflammatory mechanical hyperalgesia through action at peripheral receptors in rats. Eur J Pharmacol. 2004 Nov 3;504(1-2):45-53. |
| Unit | Bottle |
| Specification | 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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