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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Neuronal Signal Pathway > BRL-54443CAS：57477-39-1
Molecular Formula：C14H18N2O
Molecular Weight：230.31
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Solid
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| CAS | 57477-39-1 |
| Name | BRL-54443 |
| Molecular Formula | C14H18N2O |
| Molecular Weight | 230.31 |
| Solubility | Soluble in DMSO ≥5mg/mL |
| Purity | ≥98% |
| Appearance | Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD01861184 |
| SMILES | CN1CCC(CC1)C2=CNC3=C2C=C(C=C3)O |
| InChIKey | WKNFADCGOAHBPG-UHFFFAOYSA-N |
| InChI | InChI=1S/C14H18N2O/c1-16-6-4-10(5-7-16)13-9-15-14-3-2-11(17)8-12(13)14/h2-3，8-10，15，17H，4-7H2，1H3 |
| PubChem CID | 2438 |
| Target Point | 5-HT Receptor |
| Passage | Neuronal Signaling；GPCR & G Protein |
| Background | BRL-54443 is a 5-HT1E and 5-HT1F receptor agonist. |
| Biological Activity | BRL 54443 是一种强效的 5-HT1E和5-HT1F受体激动剂（Ki 值分别为 1.1 nM 和 0.7 nM），对5-HT1A，5-HT1B，5-HT1D受体具有弱的结合亲和力。[1] |
| Data Literature Source | [1]. Klein MT，et al. Toward selective drug development for the human 5-hydroxytryptamine 1E receptor: a comparison of 5-hydroxytryptamine 1E and 1F receptor structure-affinity relationships. J Pharmacol Exp Ther. 2011 Jun;337(3):860-7. [2]. McKune CM，et al. Characterization of the serotonin receptor mediating contraction in the mouse thoracic aorta and signal pathway coupling. J Pharmacol Exp Ther. 2001 Apr;297(1):88-95. [3]. Klein MT，et al. Distribution of 5-ht(1E) receptors in the mammalian brain and cerebral vasculature: an immunohistochemical and pharmacological study. Br J Pharmacol. 2012 Jun;166(4):1290-302. [4]. Granados-Soto V，et al. The role of peripheral 5-HT1A，5-HT1B，5-HT1D，5-HT1E and 5-HT1F serotonergic receptors in the reduction of nociception in rats. Neuroscience. 2010 Jan 20;165(2):561-8. |
| Unit | Bottle |
| Specification | 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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