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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Neuronal Signal Pathway > CorydalineCAS：518-69-4
Molecular Formula：C22H27NO4
Molecular Weight：369.45
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 518-69-4 |
| Name | Corydaline |
| Molecular Formula | C22H27NO4 |
| Molecular Weight | 369.45 |
| Solubility | Soluble in DMSO ≥3mg/mL |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00065280 |
| SMILES | CC1C2C3=CC(=C(C=C3CCN2CC4=C1C=CC(=C4OC)OC)OC)OC |
| InChIKey | VRSRXLJTYQVOHC-YEJXKQKISA-N |
| InChI | InChI=1S/C22H27NO4/c1-13-15-6-7-18(24-2)22(27-5)17(15)12-23-9-8-14-10-19(25-3)20(26-4)11-16(14)21(13)23/h6-7，10-11，13，21H，8-9，12H2，1-5H3/t13-，21+/m0/s1 |
| PubChem CID | 101301 |
| Target Point | AChE |
| Passage | Neuronal Signaling |
| Background | It is an acetylcholinesterase inhibitor. |
| Biological Activity | Corydaline 是从延胡索堇菜中分离出来的一种异喹啉生物碱，是一种 AChE 抑制剂，其 IC50 值为 226 μM。也是一种μ-阿片受体激动剂，Ki值为1.23 μM。可抑制肠病毒71（EV71）的复制，IC50为25.23 μM。具有抗血管生成、抗过敏、抗痛觉等活性。[1-3] |
| Data Literature Source | [1]. Xiao HT，et al. Acetylcholinesterase inhibitors from Corydalis yanhusuo. Nat Prod Res. 2011 Sep;25(15):1418-22. [2]. Wang HQ，et al. Corydaline inhibits enterovirus 71 replication by regulating COX-2 expression. J Asian Nat Prod Res. 2017 Nov;19(11):1124-1133. [3]. Kaserer T，et al. Identification and characterization of plant-derived alkaloids，corydine and corydaline，as novel mu opioid receptor agonists. Sci Rep. 2020 Aug 14;10(1):13804. |
| Unit | Bottle |
| Specification | 1mg 2mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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