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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Neuronal Signal Pathway > Cyproheptadine Hydrochloride SesquihydrateCAS：41354-29-4
Molecular Formula：C21H21N·3/2H2O·HCl
Molecular Weight：350.88
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 41354-29-4 |
| Name | Cyproheptadine Hydrochloride Sesquihydrate |
| Molecular Formula | C21H21N·3/2H2O·HCl |
| Molecular Weight | 350.88 |
| Solubility | Soluble in DMSO ≥3mg/mL |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 213-535-1 |
| MDL | MFCD00012538 |
| SMILES | CN1CCC(=C2C3=CC=CC=C3C=CC4=CC=CC=C42)CC1.CN1CCC(=C2C3=CC=CC=C3C=CC4=CC=CC=C42)CC1.O.O.O.Cl.Cl |
| InChIKey | ZEAUHIZSRUAMQG-UHFFFAOYSA-N |
| InChI | InChI=1S/2C21H21N.2ClH.3H2O/c2*1-22-14-12-18(13-15-22)21-19-8-4-2-6-16(19)10-11-17-7-3-5-9-20(17)21;;;;;/h2*2-11H，12-15H2，1H3;2*1H;3*1H2 |
| PubChem CID | 11954233 |
| Target Point | 5-HT Receptor;SETD7/9 |
| Passage | Neuronal Signaling；GPCR & G Protein;Epigenetics |
| Background | It is a non-selective 5HT2 antagonist; It is also an inhibitor of SETD7/9. |
| Biological Activity | Cyproheptadine Hydrochloride 是一种非选择性的 5HT2 受体拮抗剂，其IC50为0.6 nM，也是一种 SETD7/9 抑制剂。[1-3] |
| IC50 | 5-HT2: 0.6nM(IC50)[1];SETD7/9: 1μM(IC50)[3] |
| Data Literature Source | [1]. Saeed SA，et al. Synergism interaction between arachidonic acid by 5-hydroxytryptamine in human platelet aggregation is mediated through multiple signalling pathways. Acta Pharmacol Sin. 2003 Oct;24(10):958-64. [2]. Honda M，et al. Tricyclic analogs cyclobenzaprine，amitriptyline and cyproheptadine inhibit the spinal reflex transmission through 5-HT(2) receptors. Eur J Pharmacol. 2003 Jan 1;458(1-2):91-9. [3]. Takemoto Y，et al. Identification of Cyproheptadine as an Inhibitor of SET Domain Containing Lysine Methyltransferase 7/9 (Set7/9) That Regulates Estrogen-Dependent Transcription. J Med Chem. 2016 Apr 28;59(8):3650-60. |
| Unit | Bottle |
| Specification | 25mg 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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