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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Neuronal Signal Pathway > KetanserinCAS：74050-98-9
Molecular Formula：C22H22FN3O3
Molecular Weight：395.43
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 74050-98-9 |
| Name | Ketanserin |
| Molecular Formula | C22H22FN3O3 |
| Molecular Weight | 395.43 |
| Solubility | Soluble in DMSO(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 277-680-2 |
| MDL | MFCD00083392 |
| SMILES | C1CN(CCC1C(=O)C2=CC=C(C=C2)F)CCN3C(=O)C4=CC=CC=C4NC3=O |
| InChIKey | FPCCSQOGAWCVBH-UHFFFAOYSA-N |
| InChI | InChI=1S/C22H22FN3O3/c23-17-7-5-15(6-8-17)20(27)16-9-11-25(12-10-16)13-14-26-21(28)18-3-1-2-4-19(18)24-22(26)29/h1-8，16H，9-14H2，(H，24，29) |
| PubChem CID | 3822 |
| Target Point | 5-HT Receptor |
| Passage | Neuronal Signaling；GPCR & G Protein |
| Background | Ketanserin is a selective 5-HT2 receptor antagonist. |
| Biological Activity | Ketanserin 是一种选择性 5-HT2 受体拮抗剂，以浓度依赖性方式（IC50=0.11 μM）阻断 hERG 电流（IhERG）。[1] |
| IC50 | hERG current: 0.11μM(IC50)[1] |
| Data Literature Source | [1]. Tang Q，et alR. The 5-HT2 antagonist ketanserin is an open channel blocker of human cardiac ether-à-go-go-related gene (hERG) potassium channels. Br J Pharmacol. 2008 Oct;155(3):365-73. [2]. Khan N，et al. Investigation of cyclooxygenase and signaling pathways involved in human platelet aggregation mediated by synergistic interaction of various agonists. Drug Des Devel Ther. 2015 Jul 6;9:3497-506. [3]. Jiang DG，et al. Serotonin regulates brain-derived neurotrophic factor expression in select brain regions during acute psychological stress. Neural Regen Res. 2016 Sep;11(9):1471-1479. |
| Unit | Bottle |
| Specification | 50mg 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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