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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Neuronal Signal Pathway > PNU-120596CAS：501925-31-1
Molecular Formula：C13H14ClN3O4
Molecular Weight：311.72
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Solid
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| CAS | 501925-31-1 |
| Name | PNU-120596 |
| Molecular Formula | C13H14ClN3O4 |
| Molecular Weight | 311.72 |
| Solubility | Soluble in DMSO ≥5mg/mL |
| Purity | ≥98% |
| Appearance | Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00095313 |
| SMILES | CC1=CC(=NO1)NC(=O)NC2=CC(=C(C=C2OC)OC)Cl |
| InChIKey | CEIIEALEIHQDBX-UHFFFAOYSA-N |
| InChI | InChI=1S/C13H14ClN3O4/c1-7-4-12(17-21-7)16-13(18)15-9-5-8(14)10(19-2)6-11(9)20-3/h4-6H，1-3H3，(H2，15，16，17，18) |
| PubChem CID | 311434 |
| Target Point | nAChR |
| Passage | Neuronal Signaling;Membrane Transporter&Ion Channel |
| Background | PNU-120596 is an effective allosteric regulator of α7 nAChR. |
| Biological Activity | PNU-120596 是一种α7 nAChR变构调节剂，EC50为216 nM。[1] |
| Data Literature Source | [1]. Hurst RS，et al. A novel positive allosteric modulator of the alpha7 neuronal nicotinic acetylcholine receptor: in vitro and in vivo characterization. J Neurosci. 2005 Apr 27;25(17):4396-405. [2]. Ng HJ，et al. Nootropic alpha7 nicotinic receptor allosteric modulator derived from GABAA receptor modulators. Proc Natl Acad Sci U S A. 2007 May 8;104(19):8059-64. [3]. Barron SC，et al. An allosteric modulator of alpha7 nicotinic receptors，N-(5-Chloro-2，4-dimethoxyphenyl)-N'-(5-methyl-3-isoxazolyl)-urea (PNU-120596)，causes conformational changes in the extracellular ligand binding domain similar to those caused by acetylcholine. Mol Pharmacol. 2009 Aug;76(2):253-63. [4]. Munro G，et al. The α7 nicotinic ACh receptor agonist compound B and positive allosteric modulator PNU-120596 both alleviate inflammatory hyperalgesia and cytokine release in the rat. Br J Pharmacol. 2012 Sep;167(2):421-35. |
| Unit | Bottle |
| Specification | 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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