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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Neuronal Signal Pathway > 3-Phenylsulfonyl-8-(piperazin-1-yl)quinolineCAS：607742-69-8
Molecular Formula：C19H19N3O2S
Molecular Weight：353.44
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 607742-69-8 |
| Name | 3-Phenylsulfonyl-8-(piperazin-1-yl)quinoline |
| Molecular Formula | C19H19N3O2S |
| Molecular Weight | 353.44 |
| Solubility | Soluble in DMSO ≥5mg/mL |
| Purity | ≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD12828872 |
| SMILES | C1CN(CCN1)C2=CC=CC3=CC(=CN=C32)S(=O)(=O)C4=CC=CC=C4 |
| InChIKey | JJZFWROHYSMCMU-UHFFFAOYSA-N |
| InChI | InChI=1S/C19H19N3O2S/c23-25(24，16-6-2-1-3-7-16)17-13-15-5-4-8-18(19(15)21-14-17)22-11-9-20-10-12-22/h1-8，13-14，20H，9-12H2 |
| PubChem CID | 11256720 |
| Target Point | 5-HT Receptor |
| Passage | Neuronal Signaling；GPCR & G Protein |
| Background | It is a 5-HT6 receptor antagonist. |
| Biological Activity | 3-Phenylsulfonyl-8-(piperazin-1-yl)quinoline 是一种高选择性的 5-HT6 受体拮抗剂，pKi 为 9.63；比作用于其他受体选择性高100倍以上，被用于阿尔兹海默病的研究。[1-3] |
| Data Literature Source | [1]. Callaghan CK，et al. Age-related declines in delayed non-match-to-sample performance (DNMS) are reversed by the novel 5HT6 receptor antagonist SB742457. Neuropharmacology. 2012 Oct;63(5):890-7. [2]. Maher-Edwards G，et al. Double-blind，controlled phase II study of a 5-HT6 receptor antagonist，SB-742457，in Alzheimer's disease. Curr Alzheimer Res. 2010 Aug;7(5):374-85. [3]. Upton N，et al. 5-HT6 receptor antagonists as novel cognitive enhancing agents for Alzheimer's disease. Neurotherapeutics. 2008 Jul;5(3):458-69. |
| Unit | Bottle |
| Specification | 1mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
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