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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Neuronal Signal Pathway > STO-609CAS：52029-86-4
Molecular Formula：C19H10N2O3
Molecular Weight：314.29
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 52029-86-4 |
| Name | STO-609 |
| Molecular Formula | C19H10N2O3 |
| Molecular Weight | 314.29 |
| Solubility | Soluble in DMSO(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD30685721 |
| SMILES | C1=CC=C2C(=C1)N=C3N2C(=O)C4=CC=CC5=C(C=CC3=C54)C(=O)O |
| InChIKey | MYKOWOGZBMOVBJ-UHFFFAOYSA-N |
| InChI | InChI=1S/C19H10N2O3/c22-18-13-5-3-4-10-11(19(23)24)8-9-12(16(10)13)17-20-14-6-1-2-7-15(14)21(17)18/h1-9H，(H，23，24) |
| PubChem CID | 3467590 |
| Target Point | CaMKK |
| Passage | Membrane Transporter&Ion Channel |
| Background | STO-609 is a selective and cell-permeable inhibitor of CaM-KK. |
| Biological Activity | STO-609 是一种具有选择性和细胞渗透性的 Ca2+/calmodulin 依赖性蛋白激酶（CaM-KK）抑制剂，对重组 CaM-KKα 和 CaM-KKβ 的 Ki 值分别为 80 和 15 ng/mL。STO-609 可抑制 HeLa 细胞裂解液中 AMP 活化蛋白激酶激酶（AMPKK）的活性，IC50 约为 0.02 克/mL。[1-2] |
| Data Literature Source | [1]. Tokumitsu H，et al. STO-609，a specific inhibitor of the Ca(2+)/calmodulin-dependent protein kinase kinase. J Biol Chem. 2002 May 3;277(18):15813-8. [2]. Kukimoto-Niino M，et al. Crystal structure of the Ca2 /calmodulin-dependent protein kinase kinase in complex with the inhibitor STO-609. J Biol Chem. 2011 Jun 24;286(25):22570-9. |
| Unit | Bottle |
| Specification | 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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