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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Endocrinology & Hormones > Terazosin Hydrochloride DihydrateCAS：70024-40-7
Molecular Formula：C19H30ClN5O6
Molecular Weight：459.92
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 70024-40-7 |
| Name | Terazosin Hydrochloride Dihydrate |
| Molecular Formula | C19H30ClN5O6 |
| Molecular Weight | 459.92 |
| Solubility | Soluble in DMSO(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00941408 |
| SMILES | COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4CCCO4)N)OC.O.O.Cl |
| InChIKey | NZMOFYDMGFQZLS-UHFFFAOYSA-N |
| InChI | InChI=1S/C19H25N5O4.ClH.2H2O/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14;;;/h10-11，14H，3-9H2，1-2H3，(H2，20，21，22);1H;2*1H2 |
| PubChem CID | 63016 |
| Target Point | Adrenergic Receptor |
| Passage | Endocrinology & Hormones;GPCR & G Protein；Neuronal Signaling |
| Background | It is a competitive α1-adrenoceptor antagonist. It can be used in the study of benign prostatic hyperplasia (BPH) and hypertension. |
| Biological Activity | Terazosin Hydrochloride Dihydrate 是一种长效选择性α1-肾上腺素受体拮抗剂，也能阻断 HERG 钾通道，具有治疗前列腺癌的活性。[1-5] |
| Data Literature Source | [1]. Michel MC，et al. Drugs for treatment of benign prostatic hyperplasia: affinity comparison at cloned alpha 1-adrenoceptor subtypes and in human prostate. J Auton Pharmacol. 1996 Feb;16(1):21-8. [2]. Kyprianou N，et al. Suppression of human prostate cancer cell growth by alpha1-adrenoceptor antagonists doxazosin and terazosin via induction of apoptosis. Cancer Res. 2000 Aug 15;60(16):4550-5. [3]. Thomas D，et al. Inhibition of human ether-a-go-go-related gene potassium channels by alpha 1-adrenoceptor antagonists prazosin，doxazosin，and terazosin. Naunyn Schmiedebergs Arch Pharmacol. 2004 May;369(5):462-72. [4]. Chang KL，et al. Combined effects of terazosin and genistein on a metastatic，hormone-independent human prostate cancer cell line. Cancer Lett. 2009 Apr 8;276(1):14-20. [5]. Pan SL，et al. Identification of apoptotic and antiangiogenic activities of terazosin in human prostate cancer and endothelial cells. J Urol. 2003 Feb;169(2):724-9. |
| Unit | Bottle |
| Specification | 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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