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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Membrane Transporter & Ion Channel > TetrabenazineCAS：58-46-8
Molecular Formula：C19H27NO3
Molecular Weight：317.42
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 58-46-8 |
| Name | Tetrabenazine |
| Molecular Formula | C19H27NO3 |
| Molecular Weight | 317.42 |
| Solubility | Soluble in DMSO(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINCES 200-383-6 |
| MDL | MFCD08461052 |
| SMILES | CC(C)CC1CN2CCC3=CC(=C(C=C3C2CC1=O)OC)OC |
| InChIKey | MKJIEFSOBYUXJB-UHFFFAOYSA-N |
| InChI | InChI=1S/C19H27NO3/c1-12(2)7-14-11-20-6-5-13-8-18(22-3)19(23-4)9-15(13)16(20)10-17(14)21/h8-9，12，14，16H，5-7，10-11H2，1-4H3 |
| PubChem CID | 6018 |
| Target Point | Monoamine Transporter(VMAT2) |
| Passage | Membrane Transporter&Ion Channel |
| Background | It is a reversible inhibitor of vesicular monoamine transporter VMAT2 site, which can be used in the study of hyperkinetic movement disorders such as Huntingtons disease. |
| Biological Activity | Tetrabenazine 是一种可逆的囊泡单胺转运体 (VMAT2) 的可逆抑制剂，其 Kd 值为 1.34 nM，可用于研究与亨廷顿氏病等多动性运动障碍有关的疾病。[1-3] |
| Data Literature Source | [1]. Shih JC，et al. Ketanserin and tetrabenazine abolish aggression in mice lacking monoamine oxidase A. Brain Res. 1999 Jul 24;835(2):104-12. [2]. Kitanaka N，et al. Tetrabenazine，a vesicular monoamine transporter-2 inhibitor，attenuates morphine-induced hyperlocomotion in mice through alteration of dopamine and 5-hydroxytryptamine turnover in the cerebral cortex. Pharmacol Biochem Behav. 2018 Sep;172:9-16. [3]. Podurgiel SJ，et al. The vesicular monoamine transporter (VMAT-2) inhibitor tetrabenazine induces tremulous jaw movements in rodents: implications for pharmacological models of parkinsonian tremor. Neuroscience. 2013 Oct 10;250:507-19. |
| Unit | Bottle |
| Specification | 50mg 100mg 250mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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