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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Neuronal Signal Pathway > Trifluoperazine DihydrochlorideCAS：440-17-5
Molecular Formula：C21H26Cl2F3N3S
Molecular Weight：480.42
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 440-17-5 |
| Name | Trifluoperazine Dihydrochloride |
| Molecular Formula | C21H26Cl2F3N3S |
| Molecular Weight | 480.42 |
| Solubility | Soluble in Water/DMSO(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 207-123-0 |
| MDL | MFCD00012656 |
| SMILES | CN1CCN(CC1)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)C(F)(F)F.Cl.Cl |
| InChIKey | BXDAOUXDMHXPDI-UHFFFAOYSA-N |
| InChI | InChI=1S/C21H24F3N3S.2ClH/c1-25-11-13-26(14-12-25)9-4-10-27-17-5-2-3-6-19(17)28-20-8-7-16(15-18(20)27)21(22，23)24;;/h2-3，5-8，15H，4，9-14H2，1H3;2*1H |
| PubChem CID | 66064 |
| Target Point | Dopamine Receptor;Adrenergic Receptor;NUPR1 ;calmodulin;P-glycoprotein |
| Passage | Neuronal Signaling;GPCR & G Protein;Endocrinology & Hormones;Membrane Transporter/Ion Channel; |
| Background | Trifluoperazine is an antipsychotic compound that acts by blocking central dopamine receptors. Trifluoperazine is an effective α 1-adrenergic receptor antagonist and NUPR1 inhibitor have anti-cancer activity. Trifluoperazine is a calmodulin inhibitor that also inhibits P-glycoprotein. |
| Biological Activity | Trifluoperazine Dihydrochloride 是一种多巴胺D2受体抑制剂，是一种强效的α1-肾上腺素能受体拮抗剂，一种有效的 NUPR1 抑制剂，被用作钙调蛋白抑制剂，还能抑制 P-糖蛋白，被用于治疗精神类疾病，具有抗癌活性。[1-4] |
| Data Literature Source | [1]. Santofimia-Casta o P，et al.. Ligand-based design identifies a potent NUPR1 inhibitor exerting anticancer activity via necroptosis. J Clin Invest. 2019 Mar 28;129(6):2500-2513. [2]. Huerta-Bahena J，et al. Trifluoperazine and chlorpromazine antagonize alpha 1- but not alpha2- adrenergic effects. Mol Pharmacol. 1983 Jan;23(1):67-70. [3]. Howland RH. Trifluoperazine: A Sprightly Old Drug. J Psychosoc Nurs Ment Health Serv. 2016 Jan;54(1):20-2. [3]. Ochiai H，et al. Influence of trifluoperazine on the late stage of influenza virus infection in MDCK cells. Antiviral Res. 1991 Feb;15(2):149-60. |
| Unit | Bottle |
| Specification | 100mg 250mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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