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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cytoskeleton > Latrunculin ACAS：76343-93-6
Molecular Formula：C22H31NO5S
Molecular Weight：421.55
Storage：Store at -20℃，2 years
Purity：≥98%
Appearance：A Solution in Ethanol（See label for concentration）
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| CAS | 76343-93-6 |
| Name | Latrunculin A |
| Molecular Formula | C22H31NO5S |
| Molecular Weight | 421.55 |
| Purity | ≥98% |
| Appearance | A Solution in Ethanol（See label for concentration） |
| Storage | Store at -20℃，2 years |
| MDL | MFCD27977552 |
| SMILES | CC1CCC2CC(CC(O2)(C3CSC(=O)N3)O)OC(=O)C=C(CCC=CC=C1)C |
| InChIKey | DDVBPZROPPMBLW-IZGXTMSKSA-N |
| InChI | InChI=1S/C22H31NO5S/c1-15-7-5-3-4-6-8-16(2)11-20(24)27-18-12-17(10-9-15)28-22(26，13-18)19-14-29-21(25)23-19/h3-5，7，11，15，17-19，26H，6，8-10，12-14H2，1-2H3，(H，23，25)/b4-3+，7-5-，16-11-/t15-，17-，18-，19+，22-/m1/s1 |
| PubChem CID | 445420 |
| Target Point | G-actin |
| Passage | Cytoskeleton |
| Background | Latrunculin A is an inhibitor. In addition, latrunculin A was able to bind to actin monomers and inhibit actin aggregation. |
| Biological Activity | Latrunculin A 来自 Latrunculia magnifica，是一种 G 肌动蛋白聚合抑制剂，可与肌动蛋白单体结合，抑制肌动蛋白的聚合，对 ATP-肌动蛋白、ADP-Pi-肌动蛋白、ADP-肌动蛋白和 G-肌动蛋白的 Kds 分别为 0.1、0.4、4.7 μM 和 0.19 μM。[1-2] |
| Data Literature Source | [1]. Fujiwara I，et al. Latrunculin A Accelerates Actin Filament Depolymerization in Addition to Sequestering Actin Monomers. Curr Biol. 2018 Oct 8;28(19):3183-3192.e2. [2]. Coué M，et al. Inhibition of actin polymerization by latrunculin A. FEBS Lett. 1987 Mar 23;213(2):316-8. [3]. Sayed KA，et al. Latrunculin A and its C-17-O-carbamates inhibit prostate tumor cell invasion and HIF-1 activation in breast tumor cells. J Nat Prod. 2008 Mar;71(3):396-402. [4]. Doller A，et al.. The cytoskeletal inhibitors latrunculin A and blebbistatin exert antitumorigenic properties in human hepatocellular carcinoma cells by interfering with intracellular HuR trafficking. Exp Cell Res. 2015 Jan 1;330(1):66-80. [5]. Konishi H，et al. Latrunculin a has a strong anticancer effect in a peritoneal dissemination model of human gastric cancer in mice. Anticancer Res. 2009 Jun;29(6):2091-7. |
| Unit | Bottle |
| Specification | 25ug |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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