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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Neuronal Signal Pathway > Talipexole DihydrochlorideCAS：36085-73-1
Molecular Formula：C10H17Cl2N3S
Molecular Weight：282.23
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 36085-73-1 |
| Name | Talipexole Dihydrochloride |
| Molecular Formula | C10H17Cl2N3S |
| Molecular Weight | 282.23 |
| Solubility | Soluble in DMSO(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00274573 |
| SMILES | C=CCN1CCC2=C(CC1)SC(=N2)N.Cl.Cl |
| InChIKey | DPQAXNSOFFYKDS-UHFFFAOYSA-N |
| InChI | InChI=1S/C10H15N3S.2ClH/c1-2-5-13-6-3-8-9(4-7-13)14-10(11)12-8;;/h2H，1，3-7H2，(H2，11，12);2*1H |
| PubChem CID | 104870 |
| Target Point | Adrenergic Receptor;Dopamine Receptor;5-HT Receptor |
| Passage | Endocrinology & Hormones;GPCR & G Protein；Neuronal Signaling |
| Background | It is an agonist of dopamine D2 receptor and α2-adrenergic receptor, and a 5-HT3 receptor antagonist, which can be used for anti-Parkinsons disease related studies. |
| Biological Activity | Talipexole Dihydrochloride 是一种多巴胺 D2 受体激动剂，具有α 2-肾上腺素受体激动和 5-HT3 受体拮抗特性，具有抗帕金森病活性。[1-3] |
| Data Literature Source | [1]. Domino EF，et al. Talipexole or pramipexole combinations with chloro-APB (SKF 82958) in MPTP-induced hemiparkinsonian monkeys. Eur J Pharmacol. 1997 May 1;325(2-3):137-44. [2]. Kohno Y，et al. Anti-tremor activity of talipexole produced by selective dopamine D2 receptor stimulation in cynomolgus monkeys with unilateral lesions in the ventromedial tegmentum. Eur J Pharmacol. 1997 Jan 29;319(2-3):197-205. [3]. Robertson GS，et al. In vivo comparisons of the effects of quinpirole and the putative presynaptic dopaminergic agonists B-HT 920 and SND 919 on striatal dopamine and acetylcholine release. J Pharmacol Exp Ther. 1993 Mar;264(3):1344-51. |
| Unit | Bottle |
| Specification | 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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