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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Membrane Transporter & Ion Channel > SinapineCAS：18696-26-9
Molecular Formula：C16H24NO5
Molecular Weight：310.36
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 18696-26-9 |
| Name | Sinapine |
| Molecular Formula | C16H24NO5 |
| Molecular Weight | 310.36 |
| Solubility | Soluble in DMSO(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| SMILES | C[N+](C)(C)CCOC(=O)C=CC1=CC(=C(C(=C1)OC)O)OC |
| InChIKey | HUJXHFRXWWGYQH-UHFFFAOYSA-O |
| InChI | InChI=1S/C16H23NO5/c1-17(2，3)8-9-22-15(18)7-6-12-10-13(20-4)16(19)14(11-12)21-5/h6-7，10-11H，8-9H2，1-5H3/p+1 |
| PubChem CID | 5280385 |
| Target Point | P-glycoprotein |
| Passage | Membrane Transporter&Ion Channel |
| Background | Sinapine is a kind of alkaloid in the seed of cruciferous plant, which has good antioxidant activity. Sinapine plays an important role in down-regulating P-gp expression by inhibiting FGFR4-FRS2α-ERK1/2 signaling pathway. |
| Biological Activity | Sinapine 是一种从十字花科物种的种子中分离出来的生物碱，具有具有抗炎和抗氧化作用作用。通过下调 P-glycoprotein 来抑制Caco-2细胞的增殖。[1-3] |
| Data Literature Source | [1]. Boulghobra D，et al. Sinapine，but not sinapic acid，counteracts mitochondrial oxidative stress in cardiomyocytes. Redox Biol. 2020 Jul;34:101554. [2]. Li Y ，Li J ，Su Q ，Liu Y . Sinapine reduces non-alcoholic fatty liver disease in mice by modulating the composition of the gut microbiota. Food Funct. 2019 Jun 19;10(6):3637-3649. [3]. Guo Y，et al. Sinapine as an active compound for inhibiting the proliferation of Caco-2 cells via downregulation of P-glycoprotein. Food Chem Toxicol. 2014 May;67:187-92. |
| Unit | Bottle |
| Specification | 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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